Prothrombin and Haemorrhage
نویسندگان
چکیده
منابع مشابه
Prothrombin complex concentrates for urgent anticoagulation reversal in patients with intracranial haemorrhage.
BACKGROUND Intracranial haemorrhage (ICH) is a serious and potentially fatal complication of oral anticoagulant therapy (OAT). Prothrombin complex concentrates (PCCs) produce a rapid and effective reversal of OAT effects, but little evidence exists on their efficacy and safety in the management of ICH in patients on OAT. AIM To evaluate the efficacy and safety of PCCs for the rapid reversal o...
متن کاملActivated prothrombin complex in the management of direct thrombin inhibitor-associated intracerebral haemorrhage.
A 78 year-old man developed sudden-onset aphasia and right hemiparesis 14 days after hospitalisation for severe cellulitis, for which he was receiving meropenem and clindamycin. His medical history included a porcine aortic valve replacement and atrial fibrillation treated with dabigatran (a direct thrombin inhibitor, DTI) 150mg twice daily. His weight was 79kg, body mass index 25mg/m, and esti...
متن کاملEmergency reversal of anticoagulation with a three-factor prothrombin complex concentrate in patients with intracranial haemorrhage.
BACKGROUND Intracranial haemorrhage is a serious and potentially fatal complication of oral anticoagulant therapy. Prothrombin complex concentrates can substantially shorten the time needed to reverse the effects of oral anticoagulants. The aim of this study was to determine the efficacy and safety of a prothrombin complex concentrate for rapid reversal of oral anticoagulant therapy in patients...
متن کاملFeasibility and clinical effectiveness of pre-hospital prothrombin complex concentrates (Octaplex/Beriplex) in anticoagulated patients with traumatic intracranial haemorrhage
Background Incidence and mortality from traumatic intra-cranial haemorrhage (ICH) is increased in patients on warfarin [1]. Prothrombin Complex Concentrates (PCC) rapidly reverse warfarin anti-coagulation and have been shown to reduce haematoma expansion and mortality in warfarinised patients sustaining ICH [2]. We aimed to determine the feasibility of pre-hospital use of PCCs by physicians and...
متن کاملProthrombin Molise: a "new" congenital dysprothrombinemia, double heterozygosis with an abnormal prothrombin and "true" prothrombin deficiency.
COAGULATION DISORDERS have represented useful clotting models. During the past decade new problems have appeared. Several conditions due to structural abnormalities of clotting factors have been described. Several dysfibrinogenemias, hemophilia B and BM variants, and factor X Friuli and other factor X variants are now well-defined clotting disorders. 1-8 Recently, two abnormal factor VII defect...
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ژورنال
عنوان ژورنال: BMJ
سال: 1954
ISSN: 0959-8138,1468-5833
DOI: 10.1136/bmj.2.4894.961